Archive for 'Oncology Quiz' Category

Cancer Quiz 2

By Kamal Saini - Last updated: Saturday, April 4, 2009

Q: The JAK2V617F  mutation is classically seen in which hematological condition? A: Polycythemia Vera (PV). In 2005, this JAK2 gain-of-function mutation was detected in patients with PV, essential thrombocythemia, and primary myelofibrosis. The 2008 WHO criteria for diagnosis of PV is as follows: Major criteria: Hgb 418.5 g/100 ml in men or 16.5 g/100 ml [...]

Cancer Quiz 1

By Kamal Saini - Last updated: Thursday, April 2, 2009

Q: What is ‘Heriditary Xerocytosis‘? A: A rare type of autosomal dominant (? chromosome 16)  hemolytic anemia, heriditary xerocytosis or dessicocytosis is caused by potassium loss from the RBC unaccompanied by a proportional gain of sodium. Clinically manifests as mild hemolysis, high MCHC, slightly high MCV, stomatocytes, target cells, and spiculated cells. Splenectomy is not [...]